obesity and diabetes risk

                          obesity and diabetes risk                                                                                                                                                                                                                                                                                                                                                             Obesity can lead to type 2 diabetes.In this case body produce enough insulin but the call got resistance against insulin.Insulin is a key for absorption  of glucose inside the cell.If body got type 2 diabetes ,insulin key cannot open the lock of cell for glucose absorption.Obesity create stress inside the cell.Endoplasmic reticulum of the cell is responsible for processing the nutrients absorbed by the cell.In case of obesity cell absorb more nutrients.Hence endoplasmic reticulum has to work more than it's normal range.Thus it produce an alarming signal to brain to lock insulin receptors at the surface of cell.This produce insulin resistance.Pancreas produces more insulin but cell cannot get it.Thus obesity has direct relation with type 2 diabetes.                            

obesity and diabetes risk

When we consume more calories than required by body ,extra calories stored as body fats on adipose tissues.When these tissues burn fats to release energy than fatty acids,hormones and proinflammatory cytokines are produced.obesity releases more fatty acids,hormones and proinflammatory cytokines.The increase release of proinflammatory cytokines  leads to chronic low grade inflammation.Chronic low grade inflammation interferes with normal signalling pathway of insulin reception of cell and produce insulin resistance.But the good news is also here. By just reducing obesity upto 10% with physical activity and stress over body,insulin resistance can be reverse.