VitamIn B1 to reverse diabetic neuropathy

Vitamin B1 to reverse diabetic neuropathy

vitamin b1 for diabetic neuropathy

                                                                                                                                                                                                                        Although vitamin b1 or Thiamine has a key role in reversing diabetic neuropathy but more specifically it's  lipid soluble derivative Benfotiamine play a key role in the reversal. Benfotiamine is synthetic s-acyl derivative of thiamine.It is a synthetic form of vitamin b1. It's absorption power is 3.6 times greater than water soluble thiamine.It penetrate the nerves more rapidly.The biological availability of benfotiamine is more as compared to water soluble thiamine.In type 2 diabetes Advanced Glycation End products(AGE)are formed as a result of bonding of sugars with lipids and proteins.This further worsen the disease as macro and micro endothelial functions disturbed.Benfotiamine reduced AGE production upto 40%.Benfotiamine improve nerves significantly and increase nerve velocity and reduce overall hbA1C.

vitamin b1 in diabetic neuropathy

            vitamin B1 in diabetic neuropathy                                                                                                                                Endothelial dysfunction is a major complication in type 2 diabetes.Nitric oxide found in blood play a major role in vasodilation.It dilate blood vessels and keep blood supply in a smooth way.In diabetic patient Nitric oxide responsible for vascular functions reduced gradually and inner lining of the arteries fails to transform blood to the tissues.Further prostaglandins and bradykinins are formed due to this irregularity.Prostaglandin and bradykinin synthesis produce pain and inflammation.Benfotiamine reduces pain and inflammation. Benfotiamine also improve blood supply and nerve regeneration in diabetic retinopathy. Synthetic form of benfotiamine available in the market by different firms recommend the dose of 600 mg per day,however you can get advice from your diabetologist. Your diabetologist may also inform you about any side effect of benfotiamine.The active response of benfotiamine comes after 3 weeks of therapy,however the symptoms of neuropathy subsidizes after 6 weeks. Together with benfotiamine ,water soluble thiamine can also help to beat diabetic neuropathy.It is available in legumes,seeds,nuts,bread,rice,cereals,and wheat. Thiamine and its derivative,benfotiamine play an important role in reversing diabetic neuropathy.